B vitamins are foundational to energy production, neurotransmitter synthesis, and neurological health — but the forms used in most supplements are not the forms the body actually needs. Standard cyanocobalamin (the cheapest form of B12) requires conversion by the liver before becoming active. For the estimated 10–15% of people with MTHFR gene variants — and many others with compromised methylation — this conversion is inefficient or impossible.
Cymbiotika's B12 + B6 formula uses all three of the most bioactive forms of B12 simultaneously: Methylcobalamin (the most studied, directly active form), Adenosylcobalamin (the mitochondrial form, supporting cellular energy production), and Hydroxocobalamin (a stable precursor form that converts to both methyl and adenosyl forms as needed). Together, they provide complete B12 coverage regardless of an individual's metabolic profile.
Active Vitamin B6 as Pyridoxal-5'-Phosphate (P5P) and Folate as Calcium L-5-Methyltetrahydrofolate (the most bioavailable methylfolate) complete the formula — addressing the full methylation cycle rather than just one pathway.

The three-form B12 approach is the formula's defining feature:
Methylcobalamin: The neurologically active form of B12. Directly supports myelin sheath integrity, neurotransmitter synthesis (serotonin, dopamine), and the methylation of homocysteine — an amino acid associated with cardiovascular and cognitive risk when elevated.
Adenosylcobalamin: The mitochondrial form of B12. Supports ATP production within the mitochondria and is particularly important for sustained physical and mental energy.
Hydroxocobalamin: A stable, long-acting form that the body converts on demand into either Methylcobalamin or Adenosylcobalamin — effectively providing a reserve pool of B12 that extends the formula's coverage.
Vitamin B6 (P5P): The active, phosphorylated form that doesn't require liver conversion. B6 is essential for the synthesis of GABA, serotonin, and dopamine — the neurotransmitters most directly linked to mood, calm, and motivation.
Folate as Calcium L-5-MTHF: The biologically active form of B9, bypassing the MTHFR enzyme entirely. Essential for DNA methylation, red blood cell formation, and neurotransmitter synthesis — and the preferred form for anyone with MTHFR variants.
Fulvic Acid: A naturally occurring compound from organic soil matter that supports mineral transport and bioavailability, and contributes antioxidant and gut integrity support to the formula.
The entire formula is delivered via liposomal technology, bypassing the gut's intrinsic factor pathway — the mechanism by which B12 absorption declines with age and in those with gut health challenges.

Pump 12 pumps (2mL) onto a spoon or directly into the mouth. Can be taken with or without food. Best taken in the morning or before 2pm to avoid any impact on sleep.
Avoid contact between the pump dispenser and the mouth to preserve freshness. Store in a cool, dark place or refrigerate after opening. Do not freeze.

• Vegans and vegetarians — B12 is found almost exclusively in animal products
• Those with known or suspected MTHFR gene variants who need active, pre-methylated B vitamins
• Anyone experiencing low energy, brain fog, poor mood, or difficulty concentrating
• Those with digestive issues or low stomach acid — who may struggle to absorb B12 via conventional supplements
  
• People supporting cardiovascular health through homocysteine management

• Three bioactive B12 forms — Methylcobalamin, Adenosylcobalamin, Hydroxocobalamin — for complete coverage
• Active B6 as P5P and active Folate as Calcium L-5-MTHF — no conversion required
• Fulvic Acid for mineral transport and gut integrity support
• Liposomal delivery bypasses the intrinsic factor pathway for reliable absorption
• Supports cellular energy, neurotransmitter synthesis, mood, and methylation
  
• Wild berry flavour — soy-free, gluten-free, sugar-free, vegan